Abstract Background The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair.Although depletion of luminal Ca2+ from the ER provokes a rapid and reversible shift towards a more reducing poise in
Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation
The transient receptor potential vanilloid 2 (TRPV2) ion channel is activated by a chemical ligand (2-aminoethoxydiphenyl borate; 2-APB), noxious heat and mechanical stimulation.In a heterologous mammalian cell expression system, the oxidant chloramine T (ChT) sensitizes TRPV2 activation in response to 2-APB and chicago skyline graffiti heat by oxi
Biochar boosts tropical but not temperate crop yields
Applying biochar to soil is thought to have multiple benefits, from helping mitigate climate change [ 1 , 2 ], to managing waste [ puddles the platypus chocolate 3 ] to conserving soil [ 4 ].Biochar is also widely assumed to boost crop yield [ 5 , 6 ], but there is controversy regarding the extent and cause of any yield benefit [ 7 ].Here we use a
Wrecked regulation of intrinsically disordered proteins in diseases: Pathogenicity of deregulated regulators
Biologically active proteins ic berlin eyewear st. louis without stable tertiary structure are common in all known proteomes.Functions of these intrinsically disordered proteins (IDPs) are typically related to regulation, signaling and control.Cellular levels of these important regulators are tightly regulated by a variety mechanisms ranging from f